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Root Cause Lab Testing

Disclaimer

The information provided on this website is for educational and informational purposes only and is not intended to be a comprehensive resource. Content may change and be updated regularly; therefore, some information may become outdated over time. This website does not offer medical advice, diagnosis, or treatment, and should not be used as a substitute for professional evaluation and care by a qualified healthcare provider. Always seek the advice of a licensed prescribing clinician, such as a nurse practitioner, psychiatrist, or other qualified medical professional, with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this website. In case of a medical or psychiatric emergency, contact your healthcare provider or emergency services immediately.

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Integrative psychiatry emphasizes a holistic approach to mental health, considering both mind and body in diagnosis and treatment. A pivotal aspect of this approach is the use of blood tests to uncover underlying physiological factors that may contribute to mental health conditions. At Mind Alchemy Mental Health, I integrate comprehensive blood testing into my practice to ensure a thorough understanding of each patient's unique biochemical makeup.

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The Role of Root Cause Lab Testing in Integrative Psychiatry

Traditional psychiatry often focuses on symptom management, sometimes overlooking potential biological contributors to mental health issues. Integrative psychiatry, however, seeks to identify and address these underlying causes. Blood tests serve as a valuable tool in this process, offering insights into various physiological aspects that can influence mental well-being.

 

Key Areas Assessed Through Blood Testing

Include but are not limited to:

1. General Health and Metabolic Function

  • Complete Blood Count with Differential (CBC w/ Diff)

    • Evaluates overall health by measuring components such as red and white blood cells and platelets.

  • Comprehensive Metabolic Panel (CMP)

    • Assesses metabolic function, including liver and kidney health, electrolyte balance, and blood glucose levels.

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2. Cardiovascular and Metabolic Health

  • Fasting Lipid Panel

    • Measures cholesterol levels to assess cardiovascular risk.

  • Hemoglobin A1c (HgA1c)

    • Provides average blood sugar levels over the past two to three months, aiding in diabetes management.

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3. Nutritional and Micronutrient Status

  • 25-Hydroxy Vitamin D

    • Evaluates vitamin D levels, essential for bone health, immune function, and mood regulation.

  • Vitamin B12 & Folic Acid Panel

    • Detects deficiencies affecting neurological function, mood, and energy levels.

  • Vitamin B6

    • Assesses B6 levels, important for neurotransmitter synthesis and cognitive function.

  • Iron, TIBC, and Ferritin Panel

    • Identifies iron deficiency or overload, impacting energy levels, cognition, and mood.

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4. Methylation and Neurological Health

  • Homocysteine

    • Elevated levels may indicate B-vitamin deficiencies and an increased risk for cardiovascular and cognitive disorders.

  • Methylmalonic Acid (MMA)

    • Used to assess B12 status more accurately, as high MMA suggests functional B12 deficiency.

  • MTHFR (Methylenetetrahydrofolate Reductase)

    • Genetic variations in the MTHFR enzyme can impact methylation, folate metabolism, and neurotransmitter production, potentially influencing mood, cognition, and overall mental health

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5. Electrolyte and Trace Mineral Balance

  • Magnesium

    • Evaluates intracellular magnesium, crucial for neuromuscular function, mood stability, and metabolic health.

  • Zinc

    • Measures intracellular zinc, essential for immune function, cognitive health, and neurotransmitter balance.

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6. Thyroid Function and Autoimmunity

  • Thyroid Panel (TSH, Free T3, Free T4, Anti-Thyroid Antibodies)

    • Assesses overall thyroid function and autoimmunity, crucial for energy regulation, mood stability, and metabolism.

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Benefits of Integrating Root Cause Lab Testing into Psychiatric Care

  • Personalized Treatment Plans

    • Understanding the unique biological factors contributing to a patient’s mental health allows for tailored interventions, increasing the likelihood of successful outcomes.

  • Early Detection of Underlying Conditions

    • Blood tests can reveal medical issues that may manifest as psychiatric symptoms, facilitating early and appropriate treatment.

  • Reduced Trial-and-Error Prescribing

    • With insights from blood tests, medication choices can be more precise, minimizing the reliance on trial-and-error approaches.

  • Enhanced Patient Engagement

    • When patients see concrete data explaining their symptoms, they often feel more empowered and engaged in their treatment plans.​

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Quest Diagnostics for Lab Work

To ensure accuracy, efficiency, and convenience in laboratory testing, I utilize Quest Diagnostics, a trusted leader in medical laboratory services. Quest Diagnostics offers:

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  • High-Quality, Reliable Testing

    • Quest Diagnostics uses advanced technology and rigorous quality control to provide precise and reliable results.

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  • Insurance and Affordable Pricing Options

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  • Fast Turnaround Times

    • Results are typically available within a few days, allowing for timely adjustments to treatment plans.

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  • Online Access to Results

    • Patients can view their lab results through the Quest Diagnostics online portal, promoting transparency and patient engagement.

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As part of my integrative psychiatric practice, I coordinate directly with Quest Diagnostics to ensure that patients receive the appropriate testing needed to uncover underlying contributors to mental health conditions. This partnership enhances the efficiency of diagnostic testing and ensures that treatment decisions are informed by the most accurate laboratory data available.

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Genova Diagnostics for Advanced Testing

To ensure comprehensive and advanced functional testing, I utilize Genova Diagnostics, a trusted leader in specialized laboratory assessments for gut health, nutrition, and metabolic function. Genova Diagnostics offers:

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Gut Health & GI Dysfunction via Genova Diagnostics GI Effects

The gut-brain axis plays a crucial role in mental health, influencing mood, cognition, and emotional regulation through interactions between the gut microbiome, immune system, and neurotransmitters (Cryan et al., 2019). Dysbiosis—an imbalance in gut bacteria—has been linked to conditions such as depression, anxiety, brain fog, and neurodevelopmental disorders (Foster et al., 2017). The Genova Diagnostics GI Effects test is a comprehensive stool analysis that evaluates gut microbiome balance, digestion, inflammation, and intestinal permeability, helping identify root causes of psychiatric symptoms that may not be apparent through conventional testing.

 

Key Areas Assessed by GI Effects

  1. Microbiome Diversity & Dysbiosis – Identifies beneficial, neutral, and pathogenic bacteria that can impact neurotransmitter production, inflammation, and immune function (Sharon et al., 2019).

  2. Intestinal Permeability ("Leaky Gut") Markers – Measures zonulin and other biomarkers associated with increased gut permeability, which has been linked to neuroinflammation, autoimmune disorders, and mood dysregulation (Mu et al., 2017).

  3. Inflammation & Immune Activation – Evaluates markers such as calprotectin and lactoferrin, which indicate gut inflammation that may contribute to psychiatric symptoms and cognitive dysfunction (Maes et al., 2019).

  4. Digestive Function & Enzyme Deficiencies – Assesses pancreatic elastase and other digestive enzymes to determine whether malabsorption is leading to nutrient deficiencies that impact brain function (Mörkl et al., 2018).

  5. Opportunistic Pathogens & Yeast Overgrowth – Detects the presence of Candida, bacterial overgrowth, and parasitic infections, which have been linked to chronic fatigue, brain fog, and psychiatric instability (Zalar et al., 2018).

  6. Short-Chain Fatty Acids (SCFAs) & Gut Metabolites – Measures levels of butyrate and other SCFAs, which are crucial for neuroprotection, mood regulation, and reducing inflammation (Silva et al., 2020).

 

Why Gut Health Matters in Psychiatry

The gut microbiome directly influences mental health by modulating neurotransmitter production, immune responses, and systemic inflammation. By utilizing the Genova GI Effects test, I can identify gut imbalances that may be exacerbating psychiatric symptoms and tailor a treatment plan that includes microbiome restoration, dietary modifications, and targeted supplementation.​ If you experience persistent mood, cognitive, or energy-related concerns along with digestive symptoms, this comprehensive gut health assessment may provide valuable insights to support your healing journey.

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Functional Nutrition Testing via Genova Diagnostics NutrEval

While standard blood tests offer valuable insights into metabolic and organ function, functional nutrition testing provides a more in-depth assessment of how the body processes and utilizes nutrients. The Genova Diagnostics NutrEval is a comprehensive functional test that evaluates nutrient deficiencies, mitochondrial function, oxidative stress, detoxification pathways, and gut microbiome imbalances, all of which can impact mental health (Karakas et al., 2020; Williams & Cotton, 2019).

 

Key Areas Assessed by NutrEval

  1. Nutrient Deficiencies – Identifies imbalances in vitamins, minerals, amino acids, and fatty acids that influence neurotransmitter function, mood stability, and cognitive health (Mikkelsen et al., 2016).

  2. Mitochondrial Function & Energy Production – Evaluates cellular metabolism markers to detect inefficiencies contributing to fatigue, brain fog, and mood disorders (Wallace, 2018).

  3. Oxidative Stress & Antioxidant Capacity – Measures free radical damage and antioxidant reserves, which play a role in neuroinflammation and psychiatric conditions (Salim, 2017).

  4. Neurotransmitter Precursors – Analyzes amino acids essential for serotonin, dopamine, and GABA production, helping guide targeted therapy for mood regulation and cognitive function (Fernstrom & Fernstrom, 2007).

  5. Detoxification & Toxin Burden – Assesses the body's ability to eliminate heavy metals, environmental toxins, and metabolic waste, which can contribute to neurological symptoms and cognitive dysfunction (Genuis & Kelln, 2015).

  6. Gut Microbiome & Dysbiosis Markers – Evaluates microbial metabolites that influence inflammation, neurotransmitter balance, and mental health (Clapp et al., 2017).

 

Why NutrEval is Valuable in Psychiatry

Underlying nutrient imbalances, oxidative stress, or detoxification impairments can exacerbate psychiatric symptoms or contribute to treatment resistance. By integrating NutrEval testing, I can tailor treatment plans with targeted supplementation, dietary adjustments, and lifestyle interventions to optimize brain function and mental well-being. If you're experiencing persistent mood, cognitive, or energy-related concerns, this assessment may provide the missing insights needed for a more effective, personalized approach to care.

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Implementing Lab Testing at Mind Alchemy Mental Health

At Mind Alchemy Mental Health, I prioritize a deep investigation & comprehensive assessment approach, ensuring that all potential contributing factors to mental health are explored. The integration of blood testing is a cornerstone of this methodology.

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My 4-Step Root Cause Approach:

  1. Identify Symptoms & Patterns

    1. I begin by thoroughly understanding your symptoms, their onset, duration, and impact on daily life.

  2. Uncover Root Causes

    1. Through detailed assessments, including blood tests, I identify underlying biological, psychological, and social factors contributing to your condition.

  3. Personalized Treatment Plan

    1. Based on the gathered data, I craft a treatment plan tailored to your specific needs, which may include lifestyle modifications, nutritional support, therapy, and, when necessary, medication.

  4. Ongoing Support & Adjustments

    1. I provide continuous monitoring and support, adjusting the treatment plan as needed to ensure optimal outcomes.

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Case Example: The Impact of Root Cause Lab Testing

Consider a patient experiencing persistent fatigue, low mood, and cognitive fog. Traditional approaches might attribute these symptoms solely to depression and prescribe antidepressants. However, at Mind Alchemy Mental Health, I conducted comprehensive blood testing and discovered the patient had significant vitamin D and B12 deficiencies, along with mild hypothyroidism. By addressing these specific issues through supplementation and thyroid support, the patient’s symptoms improved markedly without the need for psychiatric medication.

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Conclusion

Integrating blood tests into psychiatric evaluations embodies the essence of personalized medicine. By understanding the intricate interplay between physiological factors and mental health, I can develop more effective, individualized treatment plans. At Mind Alchemy Mental Health, I am committed to this comprehensive approach, ensuring that each patient receives the thorough care they deserve.

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Resources​

  • Genova Diagnostics

    • Link: Home | Genova Diagnostics​

      • Genova Diagnostics specializes in advanced functional and specialty lab testing to help uncover root causes of health concerns. Patients can explore a range of diagnostic tests, learn more about personalized testing options, and access resources to support their healthcare journey. Including this link empowers patients to take a deeper look at their health with precision and convenience.​

  • Quest Diagnostics

    • Link: Home | Quest Diagnostics​

      • This allows patients to schedule lab appointments, access their test results, and learn more about the blood tests they may need. Including this link will help patients take control of their lab work with convenience.

References

  • American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.). American Psychiatric Publishing.

  • Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017). Gut microbiota’s effect on mental health: The gut-brain axis. Clinical Practice, 7(4), 987-1001. https://doi.org/10.2174/1573403X13666180728025329

  • Cryan, J. F., O’Riordan, K. J., Sandhu, K. V., Peterson, V. L., & Dinan, T. G. (2019). The gut microbiome in neurological disorders. The Lancet Neurology, 18(2), 136-151. https://doi.org/10.1016/S1474-4422(18)30313-5

  • Fernstrom, J. D., & Fernstrom, M. H. (2007). Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. Journal of Nutrition, 137(6), 1539S-1547S. https://doi.org/10.1093/jn/137.6.1539S

  • Foster, J. A., Rinaman, L., & Cryan, J. F. (2017). Stress & the gut-brain axis: Regulation by the microbiome. Neurobiology of Stress, 7, 124-136. https://doi.org/10.1016/j.ynstr.2017.03.001

  • Genuis, S. J., & Kelln, K. L. (2015). Toxicant exposure and bioaccumulation: A common and potentially reversible cause of cognitive dysfunction and mental illness. Behavioral and Brain Functions, 11(1), 37. https://doi.org/10.1186/s12993-015-0071-z

  • Karakas, H. C., Stevens, L. M., Coussons-Read, M. E., & Gibb, R. K. (2020). Nutritional psychiatry: The role of diet and nutrition in mental health. American Journal of Lifestyle Medicine, 14(2), 137-150. https://doi.org/10.1177/1559827619880754

  • Maes, M., Leonard, B. E., Myint, A. M., Kubera, M., & Verkerk, R. (2019). The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation, inflammation, and tryptophan catabolite pathway. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 92, 107-114. https://doi.org/10.1016/j.pnpbp.2018.11.003

  • Mikkelsen, K., Stojanovska, L., Apostolopoulos, V., & Tierney, A. C. (2016). Cognitive decline: A vitamin perspective. Nutrition, 32(3), 537-545. https://doi.org/10.1016/j.nut.2015.10.019

  • Mörkl, S., Butler, M. I., Holl, A., Cryan, J. F., & Dinan, T. (2018). Probiotics and the microbiota-gut-brain axis: Focus on psychiatry. Current Topics in Behavioral Neurosciences, 43, 289-321. https://doi.org/10.1007/7854_2018_86

  • National Institute of Mental Health. (2023). Mental health information. Retrieved from https://www.nimh.nih.gov

  • Salim, S. (2017). Oxidative stress and psychological disorders. Current Neuropharmacology, 12(2), 140-147. https://doi.org/10.2174/1570159X12666131120230329

  • Sharon, G., Cruz, N. J., Kang, D. W., Gandal, M. J., Wang, B., Kim, Y. M., ... & Geschwind, D. H. (2019). Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice. Cell, 177(6), 1600-1618. https://doi.org/10.1016/j.cell.2019.05.004

  • Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020). The role of short-chain fatty acids in microbiota–gut–brain communication. Frontiers in Endocrinology, 11, 25. https://doi.org/10.3389/fendo.2020.00025

  • ​Wallace, D. C. (2018). Mitochondrial dysfunction in neurodegenerative disorders. Genes & Development, 32(9-10), 601-638. https://doi.org/10.1101/gad.312991.118

  • World Health Organization. (2023). Mental health and wellness. Retrieved from https://www.who.int

  • ​Zalar, B., Haslberger, A., & Peterlin, B. (2018). The role of microbiota in depression—A brief review. Psychiatria Danubina, 30(2), 136-141. https://doi.org/10.24869/psyd.2018.136

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